According to recent scientific studies, it has been observed that the risk of liver cancer increases 2-3 times in people with diabetes compared to people without diabetes.
Emphasizing that this rate is also linked to the increasing rate of obesity among diabetics, Anadolu Medical Center Medical Oncology Specialist Assoc. Dr YeÅim YÄ±ldÄ±rÄ±m said: âIn overweight people, increased blood lipids and high blood sugar levels in the body may progress to damage to liver cells and then to the development of cirrhosis or liver cancer. by various mechanisms. In our time, especially with the increase in diabetes, we see that the cases of liver cancer are on the increase. However, in the treatment of liver cancer, serious progress has been made with smart drugs in oral tablet form. Nowadays, we can achieve much more successful results with combinations of immunotherapy and molecular therapy as the first choice, âhe said.
Assoc. Dr YeÅim YÄ±ldÄ±rÄ±m spoke about the relationship between liver cancer and diabetes, as well as the latest developments in the treatment of liver cancer on February 4th, Cancer Day.
Emphasizing that liver cancer is a disease with increasing prevalence over the past two decades, Anadolu Medical Center Medical Oncology Specialist Assoc. Dr YeÅim YÄ±ldÄ±rÄ±m said: âThe most important factors causing liver cancer are chronic hepatitis B infections (50%) and hepatitis C (25%). However, in recent years, 20% of hepatocellular cancers occur after fatty liver disease accompanied by obesity, type 2 diabetes, dyslipidemia and hypertension, and cirrhosis developed on the basis of fatty liver disease, and this factor of risk gradually increases.
Diagnosis is made by MRI and tomography
Medical oncology specialist Assoc, who said patients usually see a doctor with signs of chronic liver disease and cirrhosis such as itching, jaundice, pain in the upper right abdomen, enlarged spleen, distension abdominal, bleeding, weakening, prominence of vessels in the chest. Dr YeÅim YÄ±ldÄ±rÄ±m said: âFor diagnosis, if there is any underlying cause such as hepatitis B, C, fatty liver which will cause chronic liver damage, only imaging methods can be diagnosed by MRI and tomography, because liver cancer has an image pattern in CT and MRI and biopsy not required in cases. However, in 25% of patients, there may not be an underlying cause. In this group, the diagnosis is made by biopsy â.
When planning treatment, many factors such as the location of the disease and the number of nodules should be considered.
Emphasizing that the location of the disease in the liver, the number and size of the nodules, whether there is accompanying cirrhosis, whether there are other diseases that may cause surgical inconvenience, the general condition performance and metastasis status should be assessed in detail when planning treatment, Medical Oncology Specialist Assoc. Dr YeÅim YÄ±ldÄ±rÄ±m said: âIf the disease only affects the liver, options such as surgery and transplantation can be considered by looking at the number, size, location and reserve of liver damage. “If it is not suitable for surgery, treatment can be done with methods such as radiofrequency ablation (RFA), chemoembolization, radioembolization, or radiation therapy, called topical ablative treatments.”
Combinations of immunotherapy and molecular therapy for liver cancer
Stating that if the disease is common and localized outside the liver, that is to say if it is metastatic, then systemic treatments are applied, Assoc. Dr YeÅim YÄ±ldÄ±rÄ±m said: âLiver cancer is not cancer that responds to chemotherapy, so the desired success has not been achieved in treatments for many years. However, in recent years, smart drugs in oral tablet form have started to make headway in treatments. Nowadays, much more successful results can be achieved with combinations of immunotherapy and molecular therapy as the first choice, âhe said.